The 5 Most Prescribed Drugs in the U.S. in 2024

Over 4 billion prescriptions are filled annually in the U.S., reflecting the critical role of medications in today’s healthcare. Prescription drugs help manage life-threatening conditions, alleviate chronic pain, and improve the well-being of millions of Americans.

In 2024, some medications have become essential staples in the lives of many consumers, addressing everything from heart health to mental well-being.

These top 5 drugs not only meet increasing healthcare trends but also showcase innovations that are transforming patient care and enhancing quality of life.

Ozempic/Wegovy/Rybelsus (Semaglutide)

Uses: Type 2 diabetes and weight management

This versatile drug, mostly available under brands like Ozempic and Wegovy, regulates blood sugar in patients with Type 2 diabetes and has gained significant traction as a weight-loss medication. Semaglutide’s dual treatment has made it immensely popular as demand surges for effective treatments.

Eliquis (Apixaban)

Uses: Anticoagulant

Eliquis is prescribed to prevent blood clots and reduce the risk of stroke. Its ability to provide significant cardiovascular protection with fewer side effects compared to older anticoagulants has led to widespread use.

Dupixent (Dupilumab)

Uses: Allergic and inflammatory conditions

Dupixent treats conditions like atopic dermatitis, asthma, and chronic sinusitis. Its targeted effect to reducing inflammation has revolutionized treatment for many patients with severe allergic diseases.

Humira (Adalimumab)

Uses: Autoimmune diseases

Humira is among the list for treating inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and psoriasis. Although its sales decreased due to new biosimilar competitors, it remains one of the most widely prescribed drugs.

Darzalex (Daratumumab)

Uses: Multiple myeloma

This medication is used for treating multiple myeloma, a type of blood cancer. Administered as an infusion, Darzalex works by targeting cancer cells and this way also offers new hope for patients.

Managing the costs associated with these essential prescription medications, however, remains a priority for many patients and professionals.

At CompareMedsRx, we’re here to simplify that process with our discount platform that provides you with prices across 70,000 pharmacies nationwide without compromising quality. Our site will soon be adding a feature to search for brand name drug discounts and home delivery options for both generic and brand name medications!  

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